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KMID : 0363220140520040230
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Korean Journal of Dermatology
2014 Volume.52 No. 4 p.230 ~ p.236
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The Expression of c-Jun and JunB in Various Skin Tumors
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Ko Bum-Joon
Cho Moon-Kyun
Park Young-Lip
Lee Jong-Suk
Lee Jeung-Hoon
Whang Kyu-Uang
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Abstract
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Background: c-Jun along with JunB, JunD, and the Fos group proteins comprise the core members of the activatorprotein 1 (AP1) family of transcription factors. Recently, many studies have demonstrated the key roles of AP1 inregulating a wide spectrum of biological processes, including tumorigenesis. We therefore hypothesized that c-Junand JunB influence the differentiation and malignant change of various skin tumors.
Objective: We measured the expression levels of c-Jun and JunB in different skin tumors. Methods: The expressions of c-Jun and JunB were examined by performing the immunohistochemical staining of 55specimens of skin tumors, including 13 cases of seborrheic keratosis, 4 cases of keratoacanthoma, 9 cases of actinickeratosis, 4 cases of Bowen’s disease, 4 cases of basal cell carcinoma, 16 cases of squamous cell carcinoma, and5 cases of malignant melanoma.
Results: Immunohistochemical analysis of the skin tumor tissue samples revealed a significantly higher expressionof c-Jun in malignant skin tumors (basal cell carcinoma, squamous cell carcinoma, malignant melanoma) than inbenign (seborrheic keratosis, keratoacanthoma) or premalignant skin tumors (actinic keratosis, Bowen``s disease). Theexpression of JunB, however, was significantly lower in malignant skin tumors than in benign skin tumors.
Conclusion: These findings showed that c-Jun has a positive association with skin malignancies, while JunB has anegative association with skin malignancies. The role of AP1 as key regulators of cell proliferation and epidermaltumor progression is suggested.
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KEYWORD
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AP1, c-Jun, JunB, Skin epidermal tumor
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